Velpanat Tablet

 Sofosbuvir (400mg) – Velpatasvir(100mg) (Velpanat Tablets)

The U.S. Food and Drug Administration approved Velpanat Tablet to treat adult patients with chronic hepatitis C virus (HCV) both with and without cirrhosis (advanced liver disease). For patients with moderate to severe cirrhosis (decompensate cirrhosis), Velpanat is approved for use in combination with the drug ribavirin. Velpanat is a fixed-dose combination tablet containing sofosbuvir, a drug approved in 2013, and Velpatasvir, a new drug, and is the first to treat all six significant forms of HCV.

Sofosbuvir (400mg) and Velpatasvir (100mg) is a fixed-dose combination of two direct-acting antiviral that has different mechanisms of action. Sofosbuvir is a nucleotide analog NS5B polymerase inhibitor while Velpatasvir is an NS5A inhibitor. Velpanat is a new medicine used to treat hepatitis C. It is a combination pill containing sofosbuvir (sold separately as Sovaldi) plus Velpatasvir.

Each dose contains 400 mg sofosbuvir and 100 mg Velpatasvir. The medicines include the following inactive components: Copovidone, croscarmellose sodium, magnesium stearate, and microcrystalline cellulose. The drugs are film-coated with a coating material containing the following inactive ingredients: iron oxide red, polyethylene glycol, polyvinyl alcohol, talc, and titanium dioxide.

The combination of sofosbuvir and Velpatasvir is used alone or with ribavirin (Copegus, Rebetol, and Ribasphere) to treat chronic hepatitis C (an ongoing viral infection that damages the liver). Sofosbuvir is in a class of antiviral medicines called nucleotide hepatitis C virus (HCV) NS5B polymerase inhibitors. Buy Velpatasvir is in a group of antiviral drugs called HCV NS5A replication complex inhibitors. The combination of sofosbuvir and Velpatasvir works by stopping the virus that causes hepatitis C from spreading inside the body.

Buy Velpanat contains two direct-acting antiviral drugs that target different steps of the hepatitis C virus (HCV) lifecycle. Sofosbuvir is a nucleotide analog HCV polymerase inhibitor, meaning it blocks the polymerase enzyme which the virus must use to reproduce. Velpatasvir is an HCV NS5A replication complex inhibitor that interferes with another protein HCV uses to replicate.

The recommended dose of this medication is one tablet taken by mouth, once daily. It is commonly taken for 12 weeks. Sofosbuvir – Velpatasvir can be taken with food or on an empty stomach. If you vomit within 3 hours of taking medicine, take another dose of the drug. If it is longer than 3 hours since you have taken medicine, do not take another tablet. Continue with your regular dose schedule. Finish all this medication, even if you have started to feel better. Many things can affect the dose of drugs that a person needs, such as body weight, other medical conditions, and other medications.

Multiple clinical tests evaluated the safety and efficacy of Velpanat. When taken with ribavirin, the most common side effects are:

• Headache
• Tiredness
• Anemia (low red blood cell count)
• Nausea
• Insomnia
• Diarrhea

This is not an exhaustive list of all potential side effects of Velpanat. These results are mild and nothing to worry about. Please tell your doctor if you experience any adverse reaction to the medication.

Velpanat is a once-daily oral medication. A typical dose of Velpanat contains 400mg of sofosbuvir and 100mg of Velpatasvir and can be taken with or without food. Do not start taking any medications without alerting your provider while on Velpanat. Do not stop taking Velpanat or change the dose of Velpanat without talking to your provider. If you miss a dose, call your healthcare provider or pharmacist. If you take too much Velpanat, seek help at your local emergency room immediately.

Keep out of the reach of children. Store at room temperature below 30 degrees C (86 degrees F). Throw away any unused medication after the expiration date.

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