Tadalafil Dosage for Erectile Dysfunction
What is the right Dosage of Tadalafil for different diseases?
Erectile Dysfunction is one of the most common types of sexual problems faced by millions of men across the world. Fortunately, we have got numerous medications that are quite effective against this problem. Speaking of ED medicines, Tadalafil is one medication that doctors often prescribe for men aged between 18 to 65 years.
About Tadalafil
- Tadalafil happens to be a popular selective phosphodiesterase type 5 inhibitor (PDE5 inhibitor) i,e vasodilatation pharmaceutical drug.
- This medication is associated with the treatments of erectile dysfunction (ED), pulmonary arterial hypertension (PAH), and benign prostatic hypertrophy (BPH). It was first approved in 2003 by the FDA for use in ED and later in 2009 for PAH.
- Tadalafil is one of the strongest medications when it comes to ED medicines. It is capable of demonstrating erections till about 36 hours. Hence it is often referred to as the “weekend pill”; which means if taken on a Friday night, it can still be active on Sunday morning.
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What is sildenafil?
Sildenafil is also a popular drug to fight out erectile dysfunction. It acts by inhibiting cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). It boosts up the blood vessels and greater blood circulation to particular areas of the body. Viagra happens to be one of the most well-known branded drugs, as a form of avanafil.
What is tadalafil?
Tadalafil is quite a popular medication for curing erectile dysfunction in men. It happens to be a phosphodiesterase type 5 inhibitor (PDE5 inhibitor) i.,e vasodilatation pharmaceutical drug.
Tadalafil vs Sildenafil: Key Differences Explained
| Parameters | Tadalafil | Sildenafil |
| Nature of Salt | phosphodiesterase type 5 inhibitor, | phosphodiesterase type 5 (PDE5) |
| Erection Duration | 17 to18 hours | 4 hours |
| Mechanism of Action | Works by inhibiting the effect of PDE5. This inhibition leads to penile erection due to the inflow of blood into the area. | Sildenafil has no direct relaxant effect on isolated human corpus cavernosum, but increases the effect of nitric oxide by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for the degradation of cGMP in the corpus cavernosum. When sexual stimulation causes the local release of Nitric Oxide, inhibition of PDE5 by sildenafil causes increased levels of cGMP in the corpus cavernosum, resulting in effortless muscle relaxation and inflow of blood to the corpus cavernosum. Sildenafil has no effect in the absence of sexual stimulation. |
| Dosage strengths available | 2.5 mg, 5 mg, 10 mg, and 20 mg | 25 mg /50 mg /75 mg /100 mg |
| Timing of Consumption | 30 minutes before the sexual act | 30 to 60 minutes prior to the sexual act or intercourse |
| Dissolution duration | 30 minutes | 45 minutes |
| Side effects | The most common potential adverse effect of using tadalafil are backpain, burping acid reflux, headache, stomach discomfort or pain, indigestion, muscle aches, flushing, and stuffy and runny nose. | Side effects by this drug are usually on placebo respiratory tract infection, back pain, flu syndrome, and arthralgia. In fixed-dose studies, dyspepsia (17%) and abnormal vision (11%) were more common at 100 mg than at lower doses. |
| Storage requirement | 20°C – 25°C | 20°C – 25°C |
Other Drug Interactions – Sildenafil vs Tadalafil
Both of these salts are phosphodiesterase type 5 (PDE5) inhibitors, and have similar interactions with other drugs. Hence the following drugs should be avoided while receiving a treatment involving either of these two drugs:
- Various forms of nitrates, such as isosorbide mononitrate (Monoket) and nitroglycerin (Nitrostat)
- certain blood pressure drugs, such as calcium channel blockers
- alpha-blockers, which can treat high blood pressure or an enlarged prostate
- certain pulmonary hypertension drugs, such as riociguat (Adempas)
- protease inhibitors, a class of HIV medications
- antifungal drugs, such as ketoconazole and itraconazole (Onmel, Sporanox)
- antibacterial drugs, such as clarithromycin (Biaxin)
Sildenafil or Tadalafil: Which one is better?
Both of Sildenafil and Tadalafil are phosphodiesterase type 5 inhibitors, who work in similar mechanism. However, both of them differ in terms of erection duration. Tadalafil here clearly wins the game way ahead of Sildenafil; with its longer erection projecting capacity.
But then again different patients react to these two different drugs in quite unique ways. Hence it is advised to only go with proper medical consultation from an authorized medical practitioner, before finalizing on any of these two drugs. The slightest of irresponsibility can cause much dreadful consequences to one.